https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 The Diagnostic, Therapeutic and Prognostic Relevance of Neutrophil Extracellular Traps in Polytrauma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54517 Tue 27 Feb 2024 15:46:04 AEDT ]]> Postinjury Multiple Organ Failure in Polytrauma: More Frequent and Potentially Less Deadly with Less Crystalloid https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54907 15, Abbreviated Injury Scale (AIS) Head < 3 and survived > 48 h. Demographics, physiological and shock resuscitation parameters were collected. The primary outcome was MOF defined by a Denver Score > 3. Secondary outcomes: intensive care unit length of stay (ICU LOS), ventilation days and mortality. Results: Three hundred and forty-seven patients met inclusion criteria (age 48 ± 20; ISS 30 ± 11, 248 (71%) were males and 23 (6.6%) patients died. The 74 (21%) MOF patients (maximum Denver Score: 5.5 ± 1.8; Duration; 5.6 ± 5.8 days) had higher ISS (32 ± 11 versus 29 ± 11) and were older (54 ± 19 versus 46 ± 20 years) than non-MOF patients. Mean daily Denver scores adjusted for age, sex, MOF and ISS did not change over time. Crystalloid usage decreased over the 10-year period (p value < 0.01) and PRBC increased (p value < 0.01). Baseline cumulative incidence of MOF at 28 days was 9% and competing risk analyses showed that incidence of MOF increased over time (subdistribution hazard ratio 1.14, 95% CI 1.04 to 1.23, p value < 0.01). Mortality risk showed no temporal change. ICU LOS increased over time (subdistribution hazard ratio 0.95, 95% CI 0.92 to 0.98, p value < 0.01). Ventilator days increased over time (subdistribution hazard ratio 0.94, 95% CI 0.9 to 0.97, p value < 0.01). Conclusion: The epidemiology of MOF continues to evolve. Our prospective cohort suggests an ageing population with increasing incidence of MOF, particularly in males, with little changes in injury or shock parameters, who are being resuscitated with less crystalloids, stay longer on ICU without improvement in survival.]]> Thu 21 Mar 2024 11:56:18 AEDT ]]> The treatment of traumatic shock: recent advances and unresolved questions https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17405 Sat 24 Mar 2018 08:01:40 AEDT ]]> Major Pelvic Ring Injuries: Fewer Transfusions Without Deaths from Bleeding During the Last Decade https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50552 Fri 28 Jul 2023 10:31:47 AEST ]]>